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Although DCE MRI can detect subtle changes in BBB permeability in well-controlled cohorts, differences in scanning equipment, parameters, and data processing between data collection sites can dilute these relatively small changes associated with AD and aging, which are typically one order of magnitude lower than the more robust changes of other disorders like ischemic stroke (Heye et al., 2014

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The GH/IGF-I axis GH or somatotropin is a peptide hormone produced and secreted mainly by the somatotroph cells of the anterior hypophysis (pituitary gland)

Proc Am Assoc Cancer Res 45:1304, 2004